Publications

Zain M, Bonin RP (2019). Alterations in evoked and spontaneous activity of dorsal horn wide dynamic range neurons in pathological pain: A systematic review and analysis. Pain. Published online June 2019.

Yu J, Wang DS, Bonin RP, Penna A, Alavian-Ghavanini A, Zurek AA, Rauw G, Baker GB, Orser BA(2019). Gabapentin increases expression of δ subunit-containing GABAA receptors. EBioMedicine. 42:203-213.

Whissell PD, Bang JY, Khan I, Xie YF, Parfitt GM, Grenon M, Plummer NW, Jensen P, Bonin RP, Kim JC (2019). Selective Activation of Cholecystokinin-Expressing GABA (CCK-GABA) Neurons Enhances Memory and Cognition. eNeuro. 6(1)

Cho C, Michalidis V, Lecker I, Collymore C, Hanwell D, Loka M, Danesh M, Pham C, Urban P, Bonin RP, Martin LJ (2019). Evaluating analgesic efficacy and administration route following craniotomy in mice using the grimace scale. Sci. Reports. 9(1):359.

Wang DS, Kaneshwaran K, Lei G, Mostafa F, Wang J, Lecker I, Avramescu S, Xie YF, Chan NK, Fernandez-Escobar A, Woo J, Chan D, Ramsey AJ, Sivak JM, Lee CJ, Bonin RP, Orser BA (2018). Dexmedetomidine Prevents Excessive γ-Aminobutyric Acid Type A Receptor Function after Anesthesia. Anesthesiology. 129(3):477-489.

Xie YF, Wang J, Bonin RP (2018). Optogenetic exploration and modulation of pain processing. Exp. Neurol. 306:117-121

Echeverry S, Shi XQ, Yang M, Huang H, Wu Y, Lorenzo LE, Perez-Sanchez J, Bonin RP, De Koninck Y, Zhang J (2017). Spinal microglia are required for long-term maintenance of neuropathic pain. Pain. 158(9):1792-1801.

Burma NE, Bonin RP, Leduc-Pessah H, Baimel C, Cairncross ZF, Mousseau M, Shankara JV, Stemkowski PL, Baimoukhametova D, Bains JS, Antle MC, Zamponi GW, Cahill CM, Borgland SL, De Koninck Y, Trang T (2017). Blocking microglial pannexin-1 channels alleviates morphine withdrawal in rodents. Nature Medicine. 23(3):355-360

 

Perez-Sanchez J, Lorenzo LE, Lecker IL, Zurek AA, Labrakakis C, Bridgwater EM, Orser BA, De Koninck Y & Bonin RP (2016). α5GABAA receptors mediate tonic inhibition in the spinal cord dorsal horn and constrain central sensitization. Journal of Neuroscience Research. Published online October 28.

Fuzesi T, Daviu N, Wamsteeker Cusulin J, Bonin RP & Bains JS (2016). Hypothalamic CRH neurons orchestrate complex behaviors after stress. Nature Communications. 7:11937.

Bonin RP, Wang F, Desrochers-Couture M, Boulanger M-E, Gasecka A, Cote DC. & De Koninck Y (2016). Epidural optogenetics for controlled analgesia. Molecular Pain. 1:1-11.

Khoutorsky A*, Bonin RP*, Sorge RE*, Gkogkas C, Jafarnejad M, Alain T, Perez-Sanchez J, Martin LJ, De Koninck Y, Mogil JS & Sonenberg N (2016). Translational control of nociception via 4E-binding protein-1. eLife; 4: 12002

Bonin RP (2015). Running from pain: mechanisms of exercise-mediated prevention of neuropathic pain. Pain; 156: 1585-1586.

 

Bonin RP & De Koninck Y (2015). Reconsolidation and the regulation of plasticity: moving beyond memory. Trends in Neurosciences; 38: 336-344.

 

Bonin RP & De Koninck Y (2014). A spinal analogue of memory reconsolidation enables reversal of hyperalgesia. Nature Neuroscience; 17: 1043-1045.

 

Bonin RP, Bories C & De Koninck Y (2014). A simplified up-down method (SUDO) for measuring mechanical nociception in rodents using von Frey filaments. Molecular Pain; 10: 26.

 

Bonin RP & De Koninck Y (2013). Restoring ionotropic inhibition as an analgesic strategy. Neuroscience Letters; 557: 43-51.

 

Gagnon M, Bergeron MJ, Lavertu G, Castonguay A, Tripathy S, Bonin RP, Perez-Sanchez J, Boudreau D, Wang B, Dumas L, Valade I, Bachand K, Jacob-Wagner M, Tardif C, Kianicka I, Isenring P, Attardo G, Coull JAM & De Koninck Y

(2013). Chloride extrusion enhancers as novel therapeutics for neurological diseases. Nature Medicine; 19: 1524-1528.

 

Daou I, Tuttle A, Longo G, Wieskopf J, Bonin RP, Ase A, Wood J, De Koninck Y, Ribeiro-da-Silva A, Mogil J & Seguela P

(2013). Remote optogenetic activation and sensitization of pain pathways in freely moving mice. Journal of Neuroscience; 33: 18631-18640.

 

Clarke H, Wijeysundera DN, Bonin RP, Orser B, Englesakis M, Katz J (2013). Pregabalin effective for the prevention of chronic postsurgical pain: really? In Response. Anesthesia and Analgesia; 116:508-509.

 

Bonin RP, Zurek AA, Yu J, Bayliss DA & Orser BA (2013). Hyperpolarization-activated current (Ih) is reduced in hippocampal neurons from mice lacking α5GABAA receptors. PLoS One; 8: e58679.

 

Clarke HA, Bonin RP, Orser BA, Englesakis M & Katz J (2012). The prevention of chronic postsurgical pain using gabapentin: A systematic review. Anesthesia and Analgesia; 115: 428-442.

 

Bonin RP, Labrakakis C, Eng DG, Whissel PD, De Koninck Y & Orser BA (2011). Pharmacological enhancement of δ-subunit-containing GABAA receptors that generate a tonic inhibitory conductance in spinal neurons attenuates acute nociception in mice. Pain; 152: 1317-1326.

 

Martin LJ, Zurek AA, Bonin RP, Oh GH, Kim JH, Mount H & Orser BA (2011). The memory-blocking properties of ethanol are not mediated by α5 subunit-containing γ-aminobutyric acid type A receptors. Behavioural Brain Research. 217: 379-385.

 

Martin LJ, Bonin RP & Orser BA (2009). The physiological properties and therapeutic potential of alpha5‑GABAA receptors. Biochemical Society Transactions; 37: 1334-1337.

 

Bonin RP & Orser BA (2008). GABAA receptor subtypes underlying general anesthesia. Pharmacology, Biochemistry and Behavior; 90: 105-112.

 

Bonin RP, Martin LJ, MacDonald JF & Orser BA (2007). α5GABAA receptors regulate the intrinsic excitability of mouse hippocampal pyramidal neurons. Journal of Neurophysiology; 98: 2244-2254.

 

Caraiscos VB, Bonin RP, Newell JG, Czerwinska E, MacDonald JF & Orser BA (2007). Insulin increases the function of glycine receptors by increasing the potency of glycine. Molecular Pharmacology; 71:1277-1287.

 

Cheng VY*, Bonin RP*, Chiu MW, Newell JG, MacDonald JF & Orser BA (2006). Gabapentin increases a tonic inhibitory conductance in hippocampal pyramidal neurons. Anesthesiology; 105: 325-333. 

Sager M, Padol I, Khan W, Bonin RP, Blennerhasset PA & Hunt RH (2004). Establishment of TH2 immune response based gerbil model of enteric infection. Scandinavian Journal of Gastroenterology; 39: 668-673. 

Recent and upcoming conference presentations

Recent and upcoming conference presentations

D’Souza A & Bonin RP (2016). Long-Term Facilitation in the Spinal Cord Dorsal Horn: An In Vitro Model of Pathological Pain  Processing. Pharmacy Undergraduate Studentship Research Rounds.

Patel I, D’Souza A, Lecker I, Dubins D & Bonin RP (2016). Hanging behavior in mice is a sensitive marker of animal welfare. Pharmacy Undergraduate Studentship Research Rounds.

Bonin RP (2016). Modulation of pain processing by socially-relevant gentle touch. Can. Pain Soc. Conference in Vancouver, B.C.

Yini X, Xie Y-F, De Koninck Y & Bonin RP (2016). Gap junctions regulate nociception and synaptic strength of afferent input to the spinal cord dorsal horn. Graduate Research in Pharmacy.

D’Souza A, Lecker I, Dubins D & Bonin RP (2016). Hanging behavior in mice is a sensitive marker of animal welfare. Graduate Research in Pharmacy.

Gasecka A, Bahdine M, Lapointe N, Rioux V, Perez-Sanchez J, Bonin RP, De Koninck Y & Coté DC (2016). Light distribution properties in spinal cord for optogenetic stimulation. SPIE BiOS Conference. 

Bonin RP, Wang F, Desrochers-Couture M, Boulanger M-E, Gasecka A, Cote DC & De Koninck Y (2015). Epidural fiber optic implant for spinal optogenetics. Soc. Neurosci 264.15

Desrochers-Couture M, Bonin RP, De Koninck Y, Lomanowska A (2015). Sensory afferents activated by gentle touch contribute to self-grooming and social behavior. Can. Assoc. for Neurosci. 2-F-144.

 

Funding Sources